Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.89 |
| ▸ | JAK2 | O60674 | 16/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694949 | 0.94 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2694945 | 0.94 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2692944 | 0.89 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2692949 | 0.89 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL30010121 | 0.89 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL948625 | 0.88 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL30009477 | 0.88 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL932823 | 0.85 | NTRK1 (0.88) | NTRK1JAK2 | |
| SCHEMBL932821 | 0.85 | NTRK1 (0.88) | NTRK1JAK2 | |
| SCHEMBL30009510 | 0.85 | NTRK1 (1.00) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299372-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |