Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477293 | 1.00 | BRD4 (0.56) | BRD4RAB9ADRD3MCHR1LTA4H | |
| SCHEMBL29456002 | 0.81 | BRD4 (0.56) | BRD4AR | |
| SCHEMBL17477279 | 0.81 | BRD4 (0.40) | BRD4LTA4HHRH3KCNH2 | |
| SCHEMBL19160388 | 0.80 | NAMPT (0.40) | BRD4LTA4HHRH3 | |
| SCHEMBL20014332 | 0.80 | LTA4H (0.40) | BRD4LTA4HHRH3KCNH2 | |
| SCHEMBL29455909 | 0.80 | KDM4E (0.55) | BRD4RAB9ADRD3LTA4HHRH3 | |
| SCHEMBL3080285 | 0.79 | MCHR1 (0.57) | BRD4DRD3MCHR1HRH3AR | |
| SCHEMBL17477305 | 0.78 | BRD4 (0.53) | BRD4RAB9ALTA4H | |
| SCHEMBL29455917 | 0.78 | BRD4 (0.65) | BRD4MCHR1ARKCNH2 | |
| SCHEMBL22137697 | 0.77 | BRD4 (0.67) | BRD4DRD3MCHR1HRH3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174881-B1 | [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2018-03-28 | — | — | EP | disclosed |