Tiopronin

Tiopronin

SCHEMBL19989

CC(S)C(=O)NCC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 1.00
MAPT P10636 2/20 1.00
LMNA P02545 1/20 1.00
PTGS2 P35354 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
MME P08473 6/20 0.62
ACE P12821 5/20 0.62
CPA1 P15085 1/20 0.62
ACE2 Q9BYF1 1/20 0.62
ECE1 P42892 2/20 0.53
EGLN1 Q9GZT9 2/20 0.41
HPGD P15428 1/20 0.41
MAPK1 P28482 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MEN1 O00255 1/20 0.41
BLM P54132 1/20 0.41
NPEPPS P55786 1/20 0.41
KMT2A Q03164 1/20 0.41
RNPEP Q9H4A4 1/20 0.39
ITGB3 P05106 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiopronin SCHEMBL3009491 1.00 ALDH1A1 (1.00) ALDH1A1MAPTLMNAPTGS2TDP1
Dextiopronin SCHEMBL3008854 1.00 ALDH1A1 (1.00) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL9847854 1.00 ALDH1A1 (1.00) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL3017695 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL9579107 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL1921415 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL21356578 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Dextiopronin SCHEMBL3003378 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL8219032 0.98 ALDH1A1 (0.95) ALDH1A1MAPTLMNAPTGS2TDP1
Tiopronin SCHEMBL31616369 0.85 ALDH1A1 (0.73) ALDH1A1MAPTLMNAPTGS2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8814 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636312-B2 Gold clusters (AuCs), composition and method for treatment of liver cirrhosis WUHAN VAST CONDUCT SCIENCE FOUNDATION CO., LTD. (CN) 2026-05-26 US claimed
CN-122095066-A Enzyme stabilization in protease inhibitor-containing compositions 2026-05-26 CN claimed
EP-4743449-A1 L-ARGININE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF ENYO Pharma (FR) 2026-05-20 EP claimed
EP-4743450-A1 L-LYSINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF ENYO Pharma (FR) 2026-05-20 EP claimed
EP-4743451-A1 TROMETHAMINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF ENYO Pharma (FR) 2026-05-20 EP claimed
CN-121286350-B Cultivation method for tissue culture, rapid propagation and seedling culture of asparagus 江西省农业科学院蔬菜花卉研究所 2026-05-19 CN claimed
CN-122059859-A Synthesis method of diaryl methyl sulfide under biocompatible condition 南京工业大学 2026-05-19 CN claimed
EP-4739293-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS AZURA OPHTHALMICS LTD (IL) 2026-05-13 EP claimed
EP-4739291-A2 ADMINISTRATION OF KERATOLYTICS TO OCULAR AND PERIOCULAR SURFACES AZURA OPHTHALMICS LTD (IL) 2026-05-13 EP claimed
US-12568959-B2 Organ preservation and/or perfusion solution XVIVO PERFUSION AB (SE) 2026-03-10 US claimed
EP-0096013-A1 Salts of erythromycin showing a combined therapeutic activity, process for their preparation and pharmaceutical formulations containing them NUOVO CONSORZIO SANITARIO NAZIONALE (IT) 1983-12-07 EP claimed
US-4414145-A Preparation and use of a 195M-AU-containing liquid BYK-MILLINKCRODT CIL B.V. (NL) 1983-11-08 US claimed
US-4393053-A BACTERICIDES, EXPECTORANTS REFARMED S.A. (CH) 1983-07-12 US claimed
EP-0072868-A1 CYCLODEXTRIN CLATHRATE COMPOUNDS OF SULFUR-CONTAINING COMPOUNDS SANTEN PHARMACEUTICAL CO., LTD. (JP) 1983-03-02 EP claimed
EP-0015544-B1 DERIVATIVES OF THE MERCAPTOPROPIONAMIDO-ACETIC ACID, PROCESS FOR THE PREPARATION THEREOF AND COMPOSITIONS ZAMBON S.p.A. (IT) 1983-01-05 EP claimed
EP-0060573-A1 Thiolic derivatives of erythromycin having therapeutic activity, process for their preparation and pharmaceutical compositions containing them Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) 1982-09-22 EP claimed
US-4346234-A Process for the preparation of the sodium salt of mercaptopropionylglycine GARGANI PIETRO 1982-08-24 US claimed
EP-0052909-A1 Derivative of alfa-mercaptopropionilglicine having therapeutical activity, process for its preparation and related pharmaceutical compositions Real S.a.s. di Alberto Reiner & C. (IT) 1982-06-02 EP claimed
US-4292297-A RADIODIAGNOSIS, GLUTATHIONE OR MERCAPTOPROPIONYLGLYCINE BYK-MALLINCKRODT CIL B.V. (NL) 1981-09-29 US claimed
US-4035349-A SULFHYDRYL AMINO ACIDS, ESTERS AND AMIDES, VEGETABLE PROTEIN THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1977-07-12 US claimed