Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.38 |
| ▸ | JAK3 | P52333 | 11/20 | 0.38 |
| ▸ | JAK1 | P23458 | 6/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 6/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994131 | 0.91 | JAK2 (0.43) | JAK2JAK3JAK1EIF2AK4GSK3B | |
| SCHEMBL12615148 | 0.84 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1992012 | 0.83 | JAK2 (0.45) | JAK2JAK3JAK1EIF2AK4GSK3B | |
| SCHEMBL1992013 | 0.83 | JAK2 (0.45) | JAK2JAK3JAK1EIF2AK4GSK3B | |
| SCHEMBL1995218 | 0.80 | EIF2AK4 (0.47) | EIF2AK4ADORA2AMKNK1MKNK2 | |
| SCHEMBL1995220 | 0.80 | EIF2AK4 (0.47) | EIF2AK4ADORA2AMKNK1MKNK2 | |
| SCHEMBL2038127 | 0.75 | EIF2AK4 (0.46) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1996140 | 0.75 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL12643885 | 0.74 | EIF2AK4 (0.45) | EIF2AK4 | |
| SCHEMBL1992612 | 0.74 | FLT3 (0.53) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |