Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 12/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615148 | 0.84 | EIF2AK4 (0.42) | EIF2AK4JAK2JAK3JAK1ADORA2A | |
| SCHEMBL1994131 | 0.82 | JAK2 (0.43) | EIF2AK4JAK2JAK3JAK1ADORA2A | |
| SCHEMBL1995220 | 0.79 | EIF2AK4 (0.47) | EIF2AK4ADORA2A | |
| SCHEMBL1995218 | 0.79 | EIF2AK4 (0.47) | EIF2AK4ADORA2A | |
| SCHEMBL1992451 | 0.79 | IRAK4 (0.51) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1992453 | 0.79 | IRAK4 (0.51) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1997122 | 0.79 | EIF2AK4 (0.48) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL12644109 | 0.79 | EIF2AK4 (0.48) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL15198128 | 0.79 | EIF2AK4 (0.48) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1998947 | 0.75 | JAK2 (0.38) | EIF2AK4JAK2JAK3JAK1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |