Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19989922 | 0.86 | SYK (0.38) | SYKMAP4K4CLK4 | |
| SCHEMBL19989873 | 0.86 | SYK (0.38) | SYK | |
| SCHEMBL19989939 | 0.84 | SYK (0.40) | SYKTGFBR1CCNT1CDK9 | |
| SCHEMBL19989975 | 0.83 | SYK (0.41) | SYKMAP4K4CLK4 | |
| SCHEMBL19989865 | 0.82 | SYK (0.41) | SYKTGFBR1 | |
| SCHEMBL19989744 | 0.81 | SYK (0.43) | SYKCCNT1CDK9AAK1 | |
| SCHEMBL19990100 | 0.75 | PIK3R2 (0.46) | SYK | |
| SCHEMBL19989853 | 0.74 | SYK (0.34) | SYKMAP4K4CLK4 | |
| SCHEMBL19989933 | 0.73 | PIK3R2 (0.48) | SYKAAK1 | |
| SCHEMBL19990120 | 0.72 | SYK (0.33) | SYKTGFBR1MAP4K4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, AKT1 | SYK 531/4885GAK 440/4885TGFBR1 704/4885 |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, AKT1 | SYK 531/4885GAK 440/4885TGFBR1 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.