Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19990080 | 0.90 | PIK3R2 (0.42) | PIK3R2CYP46A1TGFBR1AXLABCB1 | |
| SCHEMBL19989784 | 0.81 | PIK3R2 (0.41) | PIK3R2ALDH1A1CYP46A1TGFBR1AXL | |
| SCHEMBL19990088 | 0.81 | PIK3R2 (0.38) | PIK3R2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19988844 | 0.79 | PIK3R2 (0.40) | PIK3R2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19989758 | 0.79 | PIK3R2 (0.43) | PIK3R2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19989742 | 0.79 | KDM4E (0.49) | PIK3R2SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL19990083 | 0.78 | PIK3R2 (0.44) | PIK3R2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19990111 | 0.77 | TGFBR1 (0.34) | PIK3R2MEN1KMT2ATGFBR1LMNA | |
| SCHEMBL19989873 | 0.75 | SYK (0.38) | PIK3R2 | |
| SCHEMBL19990101 | 0.75 | PIK3R2 (0.45) | PIK3R2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, AKT1 | PIK3R2 13/4885ALDH1A1 4716/4885SMN1; SMN2 1760/4885 |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, AKT1 | PIK3R2 13/4885ALDH1A1 4716/4885SMN1; SMN2 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.