Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.57 |
| ▸ | TCF7 | P36402 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14402843 | 0.95 | CTNNB1 (0.56) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL8220146 | 0.90 | CTNNB1 (0.59) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL6340738 | 0.86 | CTNNB1 (0.56) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL8179108 | 0.83 | CTNNB1 (0.55) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL13476250 | 0.82 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL31638220 | 0.82 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL31638366 | 0.82 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL13547918 | 0.79 | CTNNB1 (0.51) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL16406917 | 0.78 | CTNNB1 (0.54) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL904751 | 0.78 | CTNNB1 (0.54) | CTNNB1TCF7MPOCCNCHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892899-B1 | IMIDAZOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRISTOL MYERS SQUIBB CO (US) | 2018-03-21 | — | — | EP | disclosed |