Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 0.59 |
| ▸ | TCF7 | P36402 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 8/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CDH1 | P12830 | 1/20 | 0.40 |
| ▸ | TCF4 | P15884 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991900 | 0.90 | CTNNB1 (0.57) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL14402843 | 0.89 | CTNNB1 (0.56) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL13548299 | 0.88 | CTNNB1 (0.47) | CTNNB1TCF7MPOCCNCCDK8 | |
| SCHEMBL8179108 | 0.86 | CTNNB1 (0.55) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL13476250 | 0.85 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL31638366 | 0.85 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL31638220 | 0.85 | CTNNB1 (0.58) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL6340738 | 0.82 | CTNNB1 (0.56) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL13547918 | 0.81 | CTNNB1 (0.51) | CTNNB1TCF7MPOCCNCHTR2A | |
| SCHEMBL16406917 | 0.81 | CTNNB1 (0.54) | CTNNB1TCF7MPOCCNCHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814367-B2 | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof | MAZE THERAPEUTICS, INC. (US) | 2023-11-14 | — | — | US | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| US-8344138-B2 | Triazinedione derivatives as GABAB receptor modulators | ADDEX PHARMA S.A. (CH) | 2013-01-01 | — | — | US | disclosed |
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814367-B2 | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof | GYS2, GYS1, PYGL | CTNNB1 899/4885TCF7 3235/4885MPO 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.