Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Methyltryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | ARG1 | P05089 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (L)-1-Methyltryptophan SCHEMBL19993 | 1.00 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84HTR2A | |
| 1-Methyltryptophan SCHEMBL14202956 | 1.00 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84HTR2A | |
| Indoximod SCHEMBL934800 | 1.00 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84HTR2A | |
| Indoximod SCHEMBL29349777 | 1.00 | MAPT (0.71) | MAPTALDH1A1RECQLGPR84HTR2A | |
| Indoximod SCHEMBL23668055 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A | |
| Indoximod SCHEMBL18395435 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A | |
| Indoximod SCHEMBL30025427 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A | |
| 1-Methyltryptophan SCHEMBL23668056 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A | |
| 1-Methyltryptophan SCHEMBL20137858 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A | |
| (L)-1-Methyltryptophan SCHEMBL31387967 | 0.99 | MAPT (0.69) | MAPTALDH1A1RECQLGPR84HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4354 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144842-A1 | PHARMACEUTICAL COMPOSITION COMPRISING TRYPTOPHAN AND PHYLLOKININ DERIVATIVE FOR USE IN TREATING PSYCHIATRIC AND PSYCHOLOGICAL CONDITIONS | TEMPLE OTORONGO LLC (US) | 2026-05-28 | — | — | US | claimed |
| CN-117186424-B | Hydrogel delivery system based on dextran groups and zwitterionic groups and anti-tumor preparation | 山东大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122036541-A | Amino acid-based ionizable lipid compound, and preparation method and application thereof | 中国科学院广州生物医药与健康研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-122036995-A | Self-cascade reinforced immunotherapeutic hydrogel based on hydroxybutyl chitosan material, and preparation method and application thereof | 沈阳药科大学 | 2026-05-15 | — | — | CN | claimed |
| US-12605469-B2 | Tumor specific antibody conjugates and uses therefor | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2026-04-21 | — | — | US | claimed |
| US-12521455-B2 | Kisspeptin receptor (KISS1R) targeted therapeutics and uses thereof | RADIONETICS ONCOLOGY, INC. (US) | 2026-01-13 | — | — | US | claimed |
| EP-4646433-A1 | ANTI-IL-18BP ANTIBODIES | Lassen Therapeutics, Inc. (US) | 2025-11-12 | — | — | EP | claimed |
| US-20250312499-A1 | KISSPEPTIN RECEPTOR (KISS1R) TARGETED THERAPEUTICS AND USES THEREOF | RADIONETICS ONCOLOGY, INC. | 2025-10-09 | — | — | US | claimed |
| US-20250188170-A1 | COMPOSITIONS AND METHODS COMPRISING ANTI-NRP2b ANTIBODIES | ATYR PHARMA, INC. | 2025-06-12 | — | — | US | claimed |
| CN-119700754-A | Application of IDO1 inhibitor in preparation of medicine for treating children sepsis-related thymus atrophy | 复旦大学附属儿科医院 | 2025-03-28 | — | — | CN | claimed |
| US-6482416-B2 | ALTERATION OF MACROPHAGE-INDUCED T CELL SUPPRESSION OR CONCENTRATION BY THE SELECTIVE ELIMINATION OR INCREASE OF TRYPTOPHAN BY ADMINISTERING AN ENZYME INHIBITOR OF INDOLE-AMINO 2,3-DEOXYGENASE; VIRICIDES; ABORTION; FERTILITY; | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. | 2002-11-19 | — | — | US | claimed |
| US-20020155104-A1 | Regulation of T cell-mediated immunity by tryptophan | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. | 2002-10-24 | — | — | US | claimed |
| US-6451840-B1 | Regulation of T cell-mediated immunity by tryptophan | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. | 2002-09-17 | — | — | US | claimed |
| EP-1185687-A1 | METHODS FOR INCREASING T CELL PROLIFERATION | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2002-03-13 | — | — | EP | claimed |
| US-20010001040-A1 | Regulation of T cell-mediated immunity by tryptophan | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. | 2001-05-10 | — | — | US | claimed |
| WO-2000066764-A1 | METHODS FOR INCREASING T CELL PROLIFERATION | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2000-11-09 | — | — | WO | claimed |
| US-5757408-A | PRINTING IMAGE ON SUBSTRATE COATED WITH AMINO-ACID DERIVATIVE ADDITIVE; QUICK DRYING OF INK, OPTICAL DENSITY, NONCURLING | XEROX CORPORATION (US) | 1998-05-26 | — | — | US | claimed |
| US-5683793-A | Ink jet transparencies | XEROX CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| US-5589277-A | INK JET PRINTING, AQUEOUS INKS, FAST DRYING | XEROX CORPORATION (US) | 1996-12-31 | — | — | US | claimed |
| EP-0667246-A1 | Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds | XEROX CORPORATION (US) | 1995-08-16 | — | — | EP | claimed |