Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11504046 | 0.79 | AKR1B1 (0.50) | AKR1B1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL14865350 | 0.75 | AKR1B1 (0.55) | AKR1B1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL9192984 | 0.72 | AKR1B1 (0.51) | AKR1B1ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL18554448 | 0.72 | AKR1B1 (0.66) | AKR1B1ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL9700040 | 0.72 | TYR (0.58) | AKR1B1ALDH1A1KDM4ECA12CA9 | |
| SCHEMBL1126991 | 0.72 | AKR1B1 (0.61) | AKR1B1ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL9734939 | 0.71 | AKR1B1 (0.50) | AKR1B1ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL21128702 | 0.71 | AKR1B1 (0.46) | AKR1B1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL11503583 | 0.71 | AKR1B1 (0.50) | AKR1B1ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL21128703 | 0.71 | AKR1B1 (0.50) | AKR1B1ALDH1A1KDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515897-B1 | PIPERAZINE CARBAMATES AS MODULATORS OF MAGL AND/OR ABHD6 AND THEIR USE | H LUNDBECK AS (DK) | 2021-08-18 | — | — | EP | disclosed |
| WO-2018053447-A1 | PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |