SCHEMBL19993281

SCHEMBL19993281

Cc1cc(Cc2cc(I)c(-c3ccc(OC(F)(F)F)cc3)c(I)c2)cc(I)c1-c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
PTGER4 P35408 1/20 0.37
PPARD Q03181 1/20 0.37
SLC6A4 P31645 1/20 0.35
ESR1 P03372 1/20 0.35
GRIN2B Q13224 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
MAPK1 P28482 1/20 0.35
PRMT6 Q96LA8 1/20 0.35
AR P10275 1/20 0.35
KIF11 P52732 1/20 0.35
SCN5A Q14524 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
SCN8A Q9UQD0 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22621280 0.91 GRIN2B (0.38) PTGER4SLC6A4GRIN2BPRMT6KIF11
SCHEMBL19993428 0.79 SLC6A4 (0.37) SLC6A4ESR1GRIN2BALDH1A1TSHR
SCHEMBL19993374 0.78
SCHEMBL22621168 0.75 FFAR4 (0.43) BCL2L1FFAR4PTGER4PPARDGRIN2B
SCHEMBL19993438 0.74 GPR3 (0.41) FFAR4KDM4EGAAMAPTMAPK1
SCHEMBL22621169 0.74 GRIA1 (0.32)
SCHEMBL22621245 0.74 SLC6A4 (0.41) FFAR4SLC6A4PRMT6ALDH1A1TSHR
SCHEMBL19993425 0.73 SCN5A (0.32) BCL2L1FFAR4SCN5A
SCHEMBL19993407 0.72 S1PR1 (0.33)
SCHEMBL19993436 0.72 KDM4E (0.36) BCL2L1FFAR4KDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018050573-A1 LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DEVICE MERCK PATENT GMBH (DE) 2018-03-22 WO disclosed