Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995581 | 0.92 | MLNR (0.62) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL2849480 | 0.88 | MLNR (0.58) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL1999376 | 0.82 | MLNR (0.54) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL2849659 | 0.80 | MLNR (0.70) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL1999380 | 0.79 | MEN1 (0.48) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL1996924 | 0.78 | MLNR (0.83) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL3658076 | 0.78 | MLNR (0.54) | MLNRMEN1KMT2AGAACYP2C9 | |
| SCHEMBL1995580 | 0.74 | MLNR (0.64) | MLNRLMNAMAPTPOLB | |
| SCHEMBL377692 | 0.74 | PKM (0.41) | MEN1KMT2AGAAKDM4ENPC1 | |
| SCHEMBL377424 | 0.74 | PKM (0.41) | MEN1KMT2AGAAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |