SCHEMBL19994151

SCHEMBL19994151

COC(=O)CN1CC(NC(=O)Nc2ccc(Cl)cc2)C(c2c(F)cc(OC)cc2F)CC1=O

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR1 P21462 20/20 0.81
FPR2 P25090 9/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19972381 0.93 FPR1 (0.81) FPR1FPR2
SCHEMBL20001249 0.90 FPR1 (1.00) FPR1FPR2
SCHEMBL19972282 0.90 FPR1 (1.00) FPR1FPR2
SCHEMBL19972279 0.90 FPR1 (1.00) FPR1FPR2
SCHEMBL19988404 0.89 FPR1 (1.00) FPR1FPR2
SCHEMBL19972342 0.89 FPR1 (1.00) FPR1FPR2
SCHEMBL19972345 0.89 FPR1 (1.00) FPR1FPR2
SCHEMBL19988710 0.86 FPR1 (0.85) FPR1FPR2
SCHEMBL19988709 0.86 FPR1 (0.85) FPR1FPR2
SCHEMBL19994138 0.86 FPR1 (0.85) FPR1FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3515902-A1 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL Grünenthal GmbH (DE) 2019-07-31 EP claimed
WO-2018054549-A1 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL Grünenthal GmbH (DE) 2018-03-29 WO claimed
EP-3515902-A1 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL Grünenthal GmbH (DE) 2019-07-31 EP disclosed
WO-2018054549-A1 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL Grünenthal GmbH (DE) 2018-03-29 WO disclosed