Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | NAMPT | P43490 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CASP6 | P55212 | 2/20 | 0.68 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.60 |
| ▸ | WNT3A | P56704 | 1/20 | 0.60 |
| ▸ | KHK | P50053 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147407 | 0.89 | POLB (0.60) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL24124854 | 0.88 | POLB (0.65) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL24124781 | 0.88 | POLB (0.64) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL7399036 | 0.84 | POLB (0.70) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL28126560 | 0.81 | TDP1 (0.65) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL27548486 | 0.81 | NAMPT (0.67) | POLBSMN1; SMN2HTTNAMPTRAB9A | |
| SCHEMBL1608633 | 0.80 | HDAC6 (1.00) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL30265442 | 0.79 | HDAC6 (0.74) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL11172 | 0.79 | HDAC6 (0.74) | POLBSMN1; SMN2HTTNAMPTKMT2A | |
| SCHEMBL29406130 | 0.79 | RAB9A (1.00) | POLBSMN1; SMN2HTTNAMPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110234640-A | Benzimidazole derivatives as anticancer agents | 利昂贝拉尔中心 | 2019-09-13 | — | — | CN | disclosed |
| EP-3515904-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | Centre Leon Berard (FR) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018054989-A1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2018-03-29 | — | — | WO | disclosed |