Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | MAOA | P21397 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | GPR183 | P32249 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19994594 | 1.00 | MAOB (0.55) | MAOBMAOAALDH1A1LMNATP53 | |
| SCHEMBL19994613 | 0.91 | MAOB (0.49) | MAOBMAOAALDH1A1LMNATP53 | |
| SCHEMBL19994612 | 0.91 | MAOB (0.49) | MAOBMAOAALDH1A1LMNATP53 | |
| SCHEMBL27153178 | 0.86 | MAOB (0.54) | MAOBMAOALMNAKMT2ANPC1 | |
| SCHEMBL27346267 | 0.86 | MAOB (0.54) | MAOBMAOALMNAKMT2ANPC1 | |
| SCHEMBL19994546 | 0.86 | MAOB (0.54) | MAOBMAOALMNAKMT2ANPC1 | |
| SCHEMBL19994634 | 0.85 | MAOB (0.55) | MAOBMAOAGPR183 | |
| SCHEMBL19994654 | 0.85 | MAOB (0.55) | MAOBMAOAKMT2ANPC1RAB9A | |
| SCHEMBL19994543 | 0.85 | MAOB (0.55) | MAOBMAOAALDH1A1LMNATP53 | |
| SCHEMBL19026545 | 0.85 | MAOB (0.43) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426634-A1 | DISUBTITUTED AZETIDINES, PYRROLIDINES, PIPERIDINES AND AZEPANES AS INHIBITORS OF MONOAMINE OXIDASE B FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | University of Ljubljana (SI) | 2019-01-16 | — | — | EP | disclosed |
| WO-2018055096-A1 | DISUBTITUTED AZETIDINES, PYRROLIDINES, PIPERIDINES AND AZEPANES AS INHIBITORS OF MONOAMINE OXIDASE B FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIVERSITY OF LJUBLJANA (SI) | 2018-03-29 | — | — | WO | disclosed |