Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987790 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL21987333 | 0.90 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL21987385 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL20954393 | 0.86 | MGAM (0.37) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL16212252 | 0.86 | GAA (0.46) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL21987727 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL20012124 | 0.80 | KMT2A (0.55) | ALDH1A1 | |
| SCHEMBL18707162 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2484547 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1GAAPOLBHTT | |
| SCHEMBL13857838 | 0.77 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GAAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515903-A1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018055402-A1 | PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |