Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 0.78 |
| ▸ | MMP2 | P08253 | 13/20 | 0.78 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.64 |
| ▸ | MMP14 | P50281 | 6/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201064 | 0.91 | ADAMTS5 (0.77) | ADAMTS5MMP2ADAM17MMP14 | |
| SCHEMBL20708493 | 0.90 | ADAMTS5 (0.78) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL17871102 | 0.88 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL22201095 | 0.85 | ADAMTS5 (0.78) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL22201145 | 0.84 | ADAMTS5 (0.78) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL20708596 | 0.82 | ADAMTS5 (0.80) | ADAMTS5MMP2ADAM17MMP14 | |
| SCHEMBL17871271 | 0.82 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL22201065 | 0.81 | ADAMTS5 (0.77) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL17871425 | 0.78 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 | |
| SCHEMBL17871225 | 0.78 | ADAMTS5 (1.00) | ADAMTS5MMP2ADAM17MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |