Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 20/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 8/20 | 1.00 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871556 | 1.00 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871251 | 0.92 | ADAMTS5 (0.84) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871239 | 0.90 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871129 | 0.90 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL19691504 | 0.88 | ADAMTS5 (0.78) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871597 | 0.87 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17884521 | 0.85 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871365 | 0.85 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17884873 | 0.84 | ADAMTS5 (0.83) | ADAMTS5ADAM17MMP2 | |
| SCHEMBL17871287 | 0.84 | ADAMTS5 (1.00) | ADAMTS5ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926281-B2 | 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis | GALAPAGOS NV (BE) | 2018-03-27 | — | — | US | disclosed |