Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356095 | 0.87 | MAPK14 (0.51) | MAPK14PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7231347 | 0.83 | MAPK1 (0.67) | MAPK14PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4771864 | 0.83 | MAPK14 (0.59) | MAPK14PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18355731 | 0.83 | MAPT (0.59) | MAPK14SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL19902355 | 0.82 | MAPK1 (0.69) | PKMSMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL17321485 | 0.79 | PKM (0.53) | MAPK14PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18933607 | 0.79 | NOTUM (0.47) | MAPK1SLC9A1 | |
| SCHEMBL20604094 | 0.75 | NR4A3 (0.56) | MAPK14PKMSMN1; SMN2MAPK1NPC1 | |
| SCHEMBL13506217 | 0.73 | MAPK1 (0.50) | PKMSMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL13990279 | 0.73 | KMT2A (0.48) | MAPK14PKMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926282-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-27 | — | — | US | disclosed |