Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675120 | 0.92 | GAA (0.53) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL17324797 | 0.90 | KDM4E (0.57) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL21947322 | 0.90 | KDM4E (0.49) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL19902561 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL19902320 | 0.89 | GAA (0.46) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL15882456 | 0.88 | KDM4E (0.51) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL15882213 | 0.88 | GAA (0.50) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL17321465 | 0.87 | KDM4E (0.50) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL19902686 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2GAAALDH1A1KDM4EPRKAB2 | |
| SCHEMBL21947319 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAALDH1A1KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926282-B2 | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-27 | — | — | US | disclosed |