Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | USP10 | Q14694 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002676 | 0.90 | LMNA (0.51) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2002655 | 0.87 | LMNA (0.51) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2003945 | 0.86 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL1998880 | 0.86 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2006666 | 0.86 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2003558 | 0.86 | LMNA (0.54) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2007797 | 0.86 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2009277 | 0.86 | LMNA (0.44) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2004372 | 0.86 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2002632 | 0.86 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2MAPTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |