Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18211368 | 0.80 | CA14 (0.43) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL16989811 | 0.72 | CA14 (0.38) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL2608081 | 0.71 | CA14 (0.49) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL9901110 | 0.70 | CA14 (0.44) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL7905771 | 0.70 | CA14 (0.44) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL20077109 | 0.68 | CA14 (0.43) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL10267170 | 0.68 | CA12 (0.43) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL22479911 | 0.68 | CA14 (0.43) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL1512279 | 0.68 | CA14 (0.43) | CA14CA12CA1CA7HDAC6 | |
| SCHEMBL6758967 | 0.68 | CA14 (0.43) | CA14CA12CA1CA7HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018057588-A1 | FURO[3,2-B]PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-29 | — | — | WO | disclosed |