Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20000945 | 0.74 | PDE2A (0.41) | GRIN2BMAPTEPHX1FAAHEPHX2 | |
| SCHEMBL21649307 | 0.71 | EPHX1 (0.46) | GRIN2BMRGPRX4SCN10AEPHX1EPHX2 | |
| SCHEMBL20831002 | 0.71 | KMT2A (0.67) | GRIN2BMRGPRX4MAPTSMN1; SMN2MAPK14 | |
| SCHEMBL5784957 | 0.69 | MRGPRX4 (0.63) | MRGPRX4MAPTSMN1; SMN2EPHX2MAOB | |
| SCHEMBL2092955 | 0.69 | TRPV1 (0.45) | GRIN2BMAPTFAAHEPHX2MAOB | |
| SCHEMBL20850495 | 0.68 | PPARG (0.47) | MRGPRX4FPR2EPHX1SERPINE1 | |
| SCHEMBL28531048 | 0.67 | EPHX1 (0.47) | GRIN2BMRGPRX4SCN9ASCN10AEPHX1 | |
| SCHEMBL11310984 | 0.65 | MRGPRX4 (0.58) | MRGPRX4MAPTSMN1; SMN2EPHX2MAOB | |
| SCHEMBL5105144 | 0.65 | MRGPRX4 (0.58) | MRGPRX4MAPTSMN1; SMN2SCN10ASERPINE1 | |
| SCHEMBL16770891 | 0.65 | SLC6A4 (0.58) | GRIN2BMRGPRX4PLA2G1BMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291358-B1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME (US) | 2018-03-28 | — | — | EP | disclosed |