Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092955 | 0.76 | TRPV1 (0.45) | TRPV1HRH3EPHX2MAPTGRIN2B | |
| SCHEMBL20000941 | 0.74 | GRIN2B (0.46) | EPHX2MAPTGRIN2BHDAC3HDAC1 | |
| SCHEMBL18154009 | 0.74 | TRPV1 (0.44) | TRPV1EPHX2MAPTGRIN2BHDAC3 | |
| SCHEMBL18154010 | 0.74 | TRPV1 (0.44) | TRPV1EPHX2MAPTGRIN2BHDAC3 | |
| SCHEMBL20821059 | 0.72 | TRPV1 (0.47) | TRPV1ALDH1A1HRH3EPHX2HDAC3 | |
| SCHEMBL18291828 | 0.72 | PDE2A (0.54) | PDE2AALDH1A1EPHX2MAPTL3MBTL1 | |
| SCHEMBL14603436 | 0.72 | PDE2A (0.46) | PDE2AALDH1A1EPHX2MAPTL3MBTL1 | |
| SCHEMBL1046494 | 0.72 | PDE2A (0.54) | PDE2AALDH1A1EPHX2MAPTL3MBTL1 | |
| SCHEMBL2088584 | 0.71 | TRPV1 (0.45) | TRPV1ALDH1A1EPHX2MAPTGRIN2B | |
| SCHEMBL10935565 | 0.71 | TRPV1 (0.49) | TRPV1ALDH1A1HRH3EPHX2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291358-B1 | GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME (US) | 2018-03-28 | — | — | EP | disclosed |