Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768413 | 0.92 | GPR119 (0.54) | GPR119MEN1KMT2AMMP13POLB | |
| SCHEMBL23204176 | 0.91 | POLB (0.46) | GPR119MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL21426511 | 0.91 | POLB (0.46) | GPR119MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL16422836 | 0.89 | HDAC1 (0.47) | GPR119MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL6881798 | 0.88 | GPR119 (0.50) | GPR119KMT2APTPN2PTPN1PTPN6 | |
| SCHEMBL6881830 | 0.88 | GPR119 (0.50) | GPR119KMT2APTPN2PTPN1PTPN6 | |
| SCHEMBL6881795 | 0.88 | GPR119 (0.50) | GPR119KMT2APTPN2PTPN1PTPN6 | |
| SCHEMBL1881361 | 0.87 | GPR119 (0.49) | GPR119PTPN2PTPN1PTPN6USP30 | |
| SCHEMBL21425790 | 0.84 | USP2 (0.47) | GPR119MEN1KMT2AHDAC1HDAC2 | |
| SCHEMBL21887032 | 0.84 | GPR119 (0.56) | GPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |