SCHEMBL2000228

SCHEMBL2000228

Fc1c(F)c(Br)c(F)c(C(F)(F)F)c1F

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30377727 1.00 TSHR (0.33) TSHRSMN1; SMN2
SCHEMBL1995717 0.94 SMN1; SMN2 (0.35) TSHRSMN1; SMN2
SCHEMBL30378537 0.92 SMN1; SMN2 (0.34) TSHRSMN1; SMN2
SCHEMBL5373278 0.92 SMN1; SMN2 (0.34) TSHRSMN1; SMN2
SCHEMBL30377798 0.88 TSHR (0.31) TSHRSMN1; SMN2
SCHEMBL28504665 0.88 TSHR (0.31) TSHRSMN1; SMN2
SCHEMBL4128954 0.86 TSHR (0.32) TSHRSMN1; SMN2
SCHEMBL1997814 0.86 TSHR (0.30) TSHRSMN1; SMN2
SCHEMBL30378024 0.86
SCHEMBL30378393 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8418530-B1 Compositions and methods for detecting leaks in HVAC/R systems MAINSTREAM ENGINEERING CORPORATION (US) 2013-04-16 US claimed
US-7960331-B2 Replacement solvents having improved properties and methods of using the same GRZYLL LAWRENCE R 2011-06-14 US claimed
US-7429557-B2 Replacement solvents having improved properties and methods of using the same MAINSTREAM ENGINEERING CORPORATION (US) 2008-09-30 US claimed
US-8418530-B1 Compositions and methods for detecting leaks in HVAC/R systems MAINSTREAM ENGINEERING CORPORATION (US) 2013-04-16 US disclosed
US-7736537-B1 Replacement solvents having improved properties for refrigeration flushes MAINSTREAM ENGINEERING CORP. (US) 2010-06-15 US disclosed
US-7566409-B1 Replacement solvents having improved properties for refrigeration flushes MAINSTREAM ENGINEERING CORPORATION (US) 2009-07-28 US disclosed
US-20090026418-A1 Replacement Solvents Having Improved Properties and Methods of Using the Same MAINSTREAM ENGINEERING CORP. (US) 2009-01-29 US disclosed
US-20090005282-A1 Replacement Solvents Having Improved Properties and Methods of Using the Same MAINSTREAM ENGINEERING CORP. (US) 2009-01-01 US disclosed
US-7429557-B2 Replacement solvents having improved properties and methods of using the same MAINSTREAM ENGINEERING CORPORATION (US) 2008-09-30 US disclosed
US-20060166851-A1 Replacement solvents having improved properties and methods of using the same MAINSTREAM ENGINEERING CORP. 2006-07-27 US disclosed
WO-2000035923-A1 CLEAN GENERATION OF A PERFLUOROARYL GRIGNARD REAGENT ALBEMARLE CORPORATION (US) 2000-06-22 WO disclosed