Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.41 |
| ▸ | FAP | Q12884 | 3/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002702 | 1.00 | DPP4 (0.41) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL20002185 | 0.84 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL20002184 | 0.84 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL21135782 | 0.84 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL19995995 | 0.84 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL20002191 | 0.84 | RIPK1 (0.44) | DPP4RIPK1NR1H2NR1H3HCAR2 | |
| SCHEMBL21052968 | 0.84 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL19995929 | 0.82 | DPP4 (0.47) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL21527857 | 0.80 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL21527858 | 0.80 | DPP4 (0.39) | DPP4DPP8DPP9DPP7FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056854-A1 | BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2018-03-29 | — | — | WO | disclosed |
| WO-2018056855-A1 | DOPAMINE-B-HYDROXYLASE INHIBITORS | BIAL - PORTELA & Cª, S.A. (PT) | 2018-03-29 | — | — | WO | disclosed |