Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18213790 | 0.85 | IDO1 (0.61) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL16886247 | 0.83 | IDO1 (0.54) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL514613 | 0.77 | IDO1 (0.66) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL3088642 | 0.77 | IDO1 (0.70) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL20267678 | 0.76 | IDO1 (0.59) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL20002888 | 0.76 | NR1I2 (0.41) | IDO1RORCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10202644 | 0.75 | IDO1 (0.58) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL23759235 | 0.74 | IDO1 (0.47) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL13677273 | 0.74 | IDO1 (0.61) | IDO1MAOBMAOACARM1PRMT6 | |
| SCHEMBL17986303 | 0.73 | IDO1 (0.66) | IDO1MAOBMAOACARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |