Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 19/20 | 0.66 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16875344 | 0.80 | RORC (1.00) | RORCNR1H2NR1H3 | |
| SCHEMBL16875346 | 0.80 | RORC (1.00) | RORCNR1H2NR1H3 | |
| SCHEMBL20002925 | 0.79 | RORC (0.64) | RORC | |
| SCHEMBL20002950 | 0.75 | RORC (0.65) | RORCNR1H2NR1H3 | |
| SCHEMBL31004988 | 0.75 | HDAC2 (0.49) | RORCHDAC2 | |
| SCHEMBL20002797 | 0.75 | RORC (0.64) | RORC | |
| SCHEMBL16875140 | 0.71 | RORC (0.85) | RORC | |
| SCHEMBL16875143 | 0.71 | RORC (0.85) | RORC | |
| SCHEMBL20002126 | 0.71 | RORC (0.62) | RORC | |
| SCHEMBL16886841 | 0.70 | RORC (0.86) | RORCNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |