Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 15/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002809 | 0.87 | RORC (0.65) | RORCNR1I2 | |
| SCHEMBL20002279 | 0.85 | RORC (0.46) | RORCPOLBMEN1KMT2A | |
| SCHEMBL20003086 | 0.85 | RORC (0.49) | RORCPOLBGAAOPRL1 | |
| SCHEMBL20003056 | 0.85 | RORC (0.49) | RORCPOLBGAAKMT2AOPRL1 | |
| SCHEMBL20003149 | 0.84 | RORC (0.57) | RORCPOLBGAAKMT2AOPRL1 | |
| SCHEMBL20002997 | 0.83 | RORC (0.67) | RORCNR1I2 | |
| SCHEMBL20003148 | 0.82 | RORC (0.46) | RORCPOLBGAAKMT2AOPRL1 | |
| SCHEMBL20003210 | 0.80 | RORC (0.49) | RORCMEN1KMT2A | |
| SCHEMBL20002923 | 0.77 | RORC (0.65) | RORC | |
| SCHEMBL16886830 | 0.76 | RORC (1.00) | RORCNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |