Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 19/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 18/20 | 0.59 |
| ▸ | CACNA1H | O95180 | 17/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17316652 | 0.94 | CACNA1I (0.65) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL28127713 | 0.85 | CACNA1G (0.58) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL17316455 | 0.75 | CACNA1I (0.73) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL15416384 | 0.75 | GAA (0.64) | — | |
| SCHEMBL17316566 | 0.74 | CACNA1I (0.72) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL17316282 | 0.74 | CACNA1I (1.00) | CACNA1ICACNA1GCACNA1HCACNA1C | |
| SCHEMBL17316503 | 0.74 | CACNA1H (0.81) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL17316277 | 0.72 | CACNA1I (0.69) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL17316425 | 0.72 | CACNA1I (0.69) | CACNA1ICACNA1GCACNA1HNPC1TP53 | |
| SCHEMBL17316536 | 0.72 | CACNA1G (0.68) | CACNA1ICACNA1GCACNA1HNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932314-B2 | Pyrazole compounds and their use as T-type calcium channel blockers | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-04-03 | — | — | US | disclosed |