Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5949941 | 0.87 | LMNA (0.78) | LMNAADRB2ADRB1TDP1ADRA1A | |
| SCHEMBL3627817 | 0.86 | LMNA (0.64) | LMNAADRB2ADRB1TDP1ADRA1A | |
| SCHEMBL1628642 | 0.84 | LMNA (0.62) | LMNAADRB2ADRB1TDP1ADRA1A | |
| SCHEMBL9721341 | 0.84 | LMNA (0.62) | LMNAADRB2ADRB1TDP1ADRA1A | |
| SCHEMBL4527180 | 0.83 | MAPT (0.50) | LMNAKDM4ETSHRMAPTPOLB | |
| SCHEMBL7787463 | 0.82 | LMNA (0.60) | LMNAADRB2ADRB1TDP1ADRA1A | |
| SCHEMBL15011707 | 0.82 | LMNA (0.64) | LMNACYP1A2MAPK1MEN1KMT2A | |
| SCHEMBL1496666 | 0.82 | LMNA (0.64) | LMNACYP1A2MAPK1MEN1KMT2A | |
| SCHEMBL8348164 | 0.81 | LMNA (0.58) | LMNAADRB2ADRB1ADRA1AADRB3 | |
| SCHEMBL11753634 | 0.80 | MAOB (0.58) | LMNAPOLBNPSR1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932309-B2 | 2-oxo-3,4-dihydropyridine-5-carboxylates and their use | UNIVERSITE DE LILLE 2 DROIT ET SANTE (FR) | 2018-04-03 | — | — | US | disclosed |