Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 19/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | RBP1 | P09455 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23176188 | 0.88 | TRPV4 (0.55) | TRPV4TRPM8RBP1 | |
| SCHEMBL20003561 | 0.86 | TRPV4 (0.55) | TRPV4TRPM8 | |
| SCHEMBL20003510 | 0.86 | TRPV4 (0.61) | TRPV4TRPM8 | |
| SCHEMBL23176371 | 0.86 | TRPV4 (0.55) | TRPV4TRPM8 | |
| SCHEMBL23614016 | 0.86 | TRPV4 (0.55) | TRPV4TRPM8 | |
| SCHEMBL20003513 | 0.86 | TRPV4 (0.61) | TRPV4TRPM8 | |
| SCHEMBL20007691 | 0.86 | RBP1 (0.53) | TRPV4TRPM8RBP1 | |
| SCHEMBL20003707 | 0.81 | TRPV4 (0.52) | TRPV4RBP1 | |
| SCHEMBL20003710 | 0.76 | TRPV4 (0.61) | TRPV4TRPM8 | |
| SCHEMBL20003580 | 0.76 | TRPV4 (0.61) | TRPV4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055526-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |