Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.56 |
| ▸ | AXL | P30530 | 7/20 | 0.56 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | MERTK | Q12866 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003880 | 0.91 | MET (0.58) | METAXLKDRMERTKRET | |
| SCHEMBL20003754 | 0.90 | MET (0.59) | METAXLKDRMERTKRET | |
| SCHEMBL20003626 | 0.86 | MET (0.56) | METAXLKDRMERTKRET | |
| SCHEMBL20003858 | 0.83 | MET (0.62) | METAXLKDRMERTKRET | |
| SCHEMBL20003965 | 0.83 | MET (0.59) | METAXLKDRMERTKRET | |
| SCHEMBL20003725 | 0.83 | MET (0.55) | METAXLKDRMERTKRET | |
| SCHEMBL20003729 | 0.81 | MET (0.57) | METAXLKDRMERTKRET | |
| SCHEMBL20003752 | 0.80 | MET (0.55) | METAXLKDRMERTKRET | |
| SCHEMBL19373358 | 0.79 | MET (0.88) | METAXLKDRMERTKRET | |
| SCHEMBL18256890 | 0.78 | MET (0.72) | METAXLKDRMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |