Sugi Predict

Sugi Predict / Compounds / Schweinfurthin A

Schweinfurthin A

Schweinfurthin A

SCHEMBL20003740

CC(C)=CCC/C(C)=C/Cc1c(O)cc(/C=C/c2cc(O)c3c(c2)CC2C(C)(C)[C@H](O)[C@H](O)C[C@@]2(C)O3)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ OSBP P22059 11/20 1.00
▸ OSBP2 Q969R2 1/20 1.00
▸ PPARG P37231 9/20 0.49
▸ PPARA Q07869 9/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Schweinfurthin A SCHEMBL847068 1.00 OSBP (1.00) OSBPOSBP2PPARGPPARA
Schweinfurthin A SCHEMBL29378071 1.00 OSBP (1.00) OSBPOSBP2PPARGPPARA
Vedelianin SCHEMBL30978359 0.92 OSBP (0.84) OSBPOSBP2PPARGPPARA
Vedelianin SCHEMBL30169535 0.92 OSBP (0.84) OSBPOSBP2PPARGPPARA
Schweinfurthin B SCHEMBL847454 0.92 OSBP (0.85) OSBPOSBP2PPARGPPARA
Schweinfurthin B SCHEMBL12042782 0.92 OSBP (0.85) OSBPOSBP2PPARGPPARA
SCHEMBL2608679 0.87 OSBP (0.85) OSBPOSBP2PPARGPPARA
Schweinfurthin E SCHEMBL24867154 0.83 OSBP (0.77) OSBPOSBP2
SCHEMBL2608676 0.81 OSBP (0.73) OSBPOSBP2
SCHEMBL12845798 0.80 OSBP (0.67) OSBPOSBP2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2432466-B1 SCHWEINFURTHINS AND USES THEREOF US HEALTH (US) 2018-03-28 — — EP disclosed