Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003733 | 0.96 | MET (0.54) | METKDRAXLRETKIT | |
| SCHEMBL20003721 | 0.94 | MET (0.55) | METKDRAXLRETKIT | |
| SCHEMBL20003898 | 0.87 | MET (0.56) | METKDRAXLRETKIT | |
| SCHEMBL20003920 | 0.86 | MET (0.51) | METKDRAXLRETKIT | |
| SCHEMBL20003927 | 0.84 | MET (0.65) | METKDRAXLRETKIT | |
| SCHEMBL20003625 | 0.82 | MET (0.56) | METKDRAXLRETKIT | |
| SCHEMBL18256893 | 0.80 | MET (0.53) | METKDRAXLRETKIT | |
| SCHEMBL20003694 | 0.80 | MET (0.65) | METKDRAXLRETKIT | |
| SCHEMBL22643700 | 0.78 | MET (0.54) | METKDRAXLRETKIT | |
| SCHEMBL18256891 | 0.78 | MET (0.61) | METKDRAXLRETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |