Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.60 |
| ▸ | AXL | P30530 | 9/20 | 0.60 |
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | MERTK | Q12866 | 4/20 | 0.57 |
| ▸ | KIT | P10721 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22643663 | 0.91 | MET (0.59) | METAXLKDRMERTKKIT | |
| SCHEMBL20003629 | 0.86 | MET (0.56) | METAXLKDRMERTKKIT | |
| SCHEMBL18256837 | 0.86 | MET (0.68) | METAXLKDRMERTKKIT | |
| SCHEMBL22643590 | 0.85 | MET (0.56) | METAXLKDRMERTKKIT | |
| SCHEMBL18256838 | 0.84 | MET (0.69) | METAXLKDRMERTKKIT | |
| SCHEMBL18256839 | 0.83 | MET (0.68) | METAXLKDRMERTKKIT | |
| SCHEMBL18256845 | 0.82 | MET (0.66) | METAXLKDRMERTKKIT | |
| SCHEMBL18256846 | 0.82 | MET (0.66) | METAXLKDRMERTKKIT | |
| SCHEMBL19373358 | 0.81 | MET (0.88) | METAXLKDRMERTKKIT | |
| SCHEMBL18256840 | 0.81 | MET (0.63) | METAXLKDRMERTKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |