Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 4/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.52 |
| ▸ | MERTK | Q12866 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003880 | 0.80 | MET (0.58) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL2479034 | 0.77 | MET (0.79) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL18256853 | 0.76 | MET (0.63) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL22643706 | 0.76 | MET (0.57) | METKITKDRFLT3AXL | |
| SCHEMBL13349061 | 0.76 | MET (0.69) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL3535935 | 0.75 | MET (0.71) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL13314728 | 0.75 | MET (0.69) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL23882436 | 0.74 | MET (0.71) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL4814497 | 0.74 | MET (0.77) | METRIPK3RIPK1LCKKIT | |
| SCHEMBL30227666 | 0.74 | MET (0.71) | METRIPK3RIPK1LCKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299369-A1 | PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2018-03-28 | — | — | EP | disclosed |