Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.83 |
| ▸ | KDR | P35968 | 5/20 | 0.83 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.83 |
| ▸ | GAK | O14976 | 1/20 | 0.83 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.83 |
| ▸ | EGFR | P00533 | 1/20 | 0.83 |
| ▸ | ESR1 | P03372 | 1/20 | 0.83 |
| ▸ | PGR | P06401 | 1/20 | 0.83 |
| ▸ | RET | P07949 | 1/20 | 0.83 |
| ▸ | ROS1 | P08922 | 1/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.83 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.83 |
| ▸ | FER | P16591 | 1/20 | 0.83 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.83 |
| ▸ | DRD1 | P21728 | 1/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.83 |
| ▸ | PDE4A | P27815 | 1/20 | 0.83 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22056011 | 0.92 | ALK (0.80) | ALKKDREML4GAKACOX3 | |
| SCHEMBL898196 | 0.91 | ALK (0.79) | ALKKDREML4GAKACOX3 | |
| SCHEMBL1756022 | 0.91 | ALK (0.79) | ALKKDREML4GAKACOX3 | |
| SCHEMBL29940275 | 0.91 | ALK (0.79) | ALKKDREML4GAKACOX3 | |
| Alectinib SCHEMBL896753 | 0.91 | ALK (1.00) | ALKKDREML4GAKACOX3 | |
| SCHEMBL29940598 | 0.91 | ALK (0.86) | ALKKDREML4GAKACOX3 | |
| Alectinib SCHEMBL29352499 | 0.91 | ALK (1.00) | ALKKDREML4GAKACOX3 | |
| SCHEMBL26972926 | 0.91 | ALK (0.86) | ALKKDREML4GAKACOX3 | |
| Alectinib SCHEMBL18631602 | 0.91 | ALK (1.00) | ALKKDREML4GAKACOX3 | |
| SCHEMBL30622252 | 0.90 | ALK (0.77) | ALKKDREML4GAKACOX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858897-B2 | Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| WO-2020249048-A1 | ALK PROTEIN REGULATOR AND ANTI-TUMOR APPLICATION THEREOF | 上海科技大学 | 2020-12-17 | — | — | WO | disclosed |
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858897-B2 | Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK | SRPK3, SRPK1, SRPK2 | ALK 4/4885KDR 1280/4885EML4 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.