SRPK3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL14555007	0.59	2/20
SCHEMBL12855755	0.59	2/20
SCHEMBL15918465	0.55	2/20
SCHEMBL407224	0.45	2/20
SCHEMBL16569887	0.41	2/20
SCHEMBL1110476	1.00	1/20
SCHEMBL1110544	1.00	1/20
SCHEMBL1646963	1.00	1/20
SCHEMBL3485927	1.00	1/20
SCHEMBL3485920	0.98	1/20
SCHEMBL1110642	0.80	1/20
SCHEMBL13540499	0.79	1/20
SCHEMBL3485129	0.78	1/20
SCHEMBL12765717	0.78	1/20
SCHEMBL3485680	0.78	1/20
SCHEMBL10820439	0.77	1/20
SCHEMBL1110612	0.77	1/20
SCHEMBL1647479	0.75	1/20
SCHEMBL3485720	0.74	1/20
SCHEMBL1647427	0.74	1/20

Clinical trials — most relevant to SRPK3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Anastrozole or Fulvestrant in Treating Postmenopausal Patients With Breast Cancer	PHASE2	COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Bristol-Myers Squibb Dasatinib Src Inhibition in Endometrial Cancer	EARLY_PHASE1	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping	nan	UNKNOWN
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population	nan	COMPLETED
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes	nan	UNKNOWN
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs	nan	UNKNOWN
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Patient's Derived Organoids for Drug Screening in Glioblastoma	nan	NOT_YET_RECRUITING
Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing	nan	RECRUITING
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Transcriptomes Breast, Ovarian and Leukocyte Hereditary Genes Predisposing to Breast and / or Ovarian Cancer	nan	COMPLETED
I-Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF)	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Molecular Disease Profile of Hematological Malignancies	nan	UNKNOWN
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
SRSF2 Gene Mutation in Patients With t-MDS/AML	nan	COMPLETED
Biocollection in MyeloDysplastic Syndrome (P-MDS)	nan	RECRUITING
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SRPK3 binder may also engage these)

Protein	Name	Similarity
B8Y466	—	1.000	B8Y466 →
Q9Z0G2	—	0.998	Q9Z0G2 →
O54781	—	0.990	O54781 →
Q9WVS8	—	0.989	Q9WVS8 →
SRPK1	SRSF protein kinase 1	0.989	landscape →
O70551	—	0.987	O70551 →
Q5R8Z4	—	0.986	Q5R8Z4 →
BRPF3	Bromodomain and PHD finger-containing protein 3	0.985	landscape →
Q09137	—	0.985	Q09137 →
O08605	—	0.984	O08605 →
DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.984	landscape →
Q96287	—	0.984	Q96287 →
Q9LM33	—	0.984	Q9LM33 →
Q9Z188	—	0.984	Q9Z188 →
Q8N2I9	—	0.983	Q8N2I9 →
P18265	—	0.983	P18265 →
Q5RHD1	—	0.983	Q5RHD1 →
Q8VHF0	—	0.983	Q8VHF0 →
Q6DN90	—	0.983	Q6DN90 →
RPS6KB2	Ribosomal protein S6 kinase beta-2	0.983	landscape →
Q5RDH5	—	0.983	Q5RDH5 →
Q8VDU5	—	0.983	Q8VDU5 →
A5PKJ4	—	0.982	A5PKJ4 →
Q4V8A3	—	0.982	Q4V8A3 →
Q9Z2R9	—	0.982	Q9Z2R9 →
Q8QZV4	—	0.982	Q8QZV4 →
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	0.982	landscape →
Q12756	—	0.982	Q12756 →
Q13415	—	0.982	Q13415 →
Q7T0B1	—	0.982	Q7T0B1 →