Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 6/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 5/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17066405 | 0.86 | CA1 (0.44) | CA1CA2CA4CA6MAPT | |
| SCHEMBL1755953 | 0.82 | CA1 (0.39) | CA1CA2CA4CA6MAPT | |
| SCHEMBL20366624 | 0.82 | CA1 (0.41) | CA1CA2CA4CA6MAPT | |
| SCHEMBL1755993 | 0.82 | CA1 (0.48) | CA1CA2CA4CA6MAPT | |
| SCHEMBL898273 | 0.81 | CA1 (0.41) | CA1CA2CA4CA6MAPT | |
| SCHEMBL897276 | 0.81 | CTSV (0.57) | CA1CA2CA4CA6MAPT | |
| SCHEMBL897959 | 0.78 | CA1 (0.43) | CA1CA2CA4CA6MAPT | |
| SCHEMBL896972 | 0.78 | CDK4 (0.46) | CA1CA2CA4CA6MAPT | |
| SCHEMBL1755952 | 0.76 | ALK (0.44) | CA1CA2CA4CA6MAPT | |
| SCHEMBL897520 | 0.76 | ALK (0.52) | CA1CA2CA4CA6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |