Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | RPLP1 | P05386 | 3/20 | 0.39 |
| ▸ | RPLP0 | P05388 | 3/20 | 0.39 |
| ▸ | RPS17 | P08708 | 3/20 | 0.39 |
| ▸ | RPSA | P08865 | 3/20 | 0.39 |
| ▸ | RPS2 | P15880 | 3/20 | 0.39 |
| ▸ | RPL35A | P18077 | 3/20 | 0.39 |
| ▸ | RPL7 | P18124 | 3/20 | 0.39 |
| ▸ | RPL17 | P18621 | 3/20 | 0.39 |
| ▸ | RPS4Y1 | P22090 | 3/20 | 0.39 |
| ▸ | RPS3 | P23396 | 3/20 | 0.39 |
| ▸ | RPS12 | P25398 | 3/20 | 0.39 |
| ▸ | RPL13 | P26373 | 3/20 | 0.39 |
| ▸ | RPL10 | P27635 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995794 | 0.85 | FLT3 (0.44) | IRAK4FLT3NRAS | |
| SCHEMBL1995796 | 0.85 | FLT3 (0.44) | IRAK4FLT3NRAS | |
| SCHEMBL1992453 | 0.83 | IRAK4 (0.51) | IRAK4FLT3NRAS | |
| SCHEMBL1992451 | 0.83 | IRAK4 (0.51) | IRAK4FLT3NRAS | |
| SCHEMBL1997366 | 0.73 | ADORA2A (0.39) | — | |
| SCHEMBL2054144 | 0.73 | ADORA2A (0.39) | — | |
| SCHEMBL21105794 | 0.72 | IRAK4 (0.74) | IRAK4MAPK10DYRK1AMAPK8FLT3 | |
| SCHEMBL2229902 | 0.72 | PCSK9 (0.41) | FLT3KCNH2RPLP1RPLP0RPS17 | |
| SCHEMBL12553163 | 0.71 | IRAK4 (0.53) | IRAK4MAPK10DYRK1AMAPK8FLT3 | |
| SCHEMBL21217156 | 0.71 | IRAK4 (0.56) | IRAK4MAPK10DYRK1AMAPK8FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |