Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 12/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997366 | 1.00 | ADORA2A (0.39) | ADORA2AEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL2001368 | 0.90 | JAK2 (0.38) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1995796 | 0.88 | FLT3 (0.44) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1995794 | 0.88 | FLT3 (0.44) | EIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL12643818 | 0.79 | EIF2AK4 (0.43) | ADORA2AEIF2AK4 | |
| SCHEMBL1993296 | 0.77 | EIF2AK4 (0.46) | EIF2AK4 | |
| SCHEMBL1996140 | 0.77 | EIF2AK4 (0.42) | ADORA2AEIF2AK4JAK2JAK3JAK1 | |
| SCHEMBL1997165 | 0.77 | EIF2AK4 (0.48) | ADORA2AEIF2AK4 | |
| SCHEMBL1997166 | 0.77 | EIF2AK4 (0.48) | ADORA2AEIF2AK4 | |
| SCHEMBL1992453 | 0.76 | IRAK4 (0.51) | EIF2AK4JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |