Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.63 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.51 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20366524 | 0.90 | ALK (0.74) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL21443289 | 0.86 | ALK (0.60) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL20004159 | 0.85 | ALK (0.58) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL897405 | 0.85 | ALK (0.61) | ALK | |
| SCHEMBL20004557 | 0.84 | ALK (0.58) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL10272294 | 0.84 | ALK (0.60) | ALKEML4 | |
| SCHEMBL898373 | 0.83 | ALK (0.74) | ALK | |
| SCHEMBL29962694 | 0.83 | ALK (0.74) | ALK | |
| SCHEMBL20004666 | 0.83 | ALK (0.60) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL20004111 | 0.82 | ALK (0.61) | ALKSRPK2SRPK1EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |