Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.60 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896718 | 0.86 | ALK (0.60) | ALKSRPK1DYRK3CLK1CLK2 | |
| SCHEMBL897356 | 0.85 | ALK (0.70) | ALKSRPK1 | |
| SCHEMBL897656 | 0.85 | ALK (0.60) | ALKSRPK1SRPK2 | |
| SCHEMBL898305 | 0.85 | SRPK1 (0.65) | ALKSRPK1DYRK3CLK1CLK2 | |
| SCHEMBL897220 | 0.83 | ALK (0.66) | ALKSRPK1 | |
| SCHEMBL20004558 | 0.83 | ALK (0.63) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL896685 | 0.82 | ALK (0.76) | ALK | |
| SCHEMBL897435 | 0.82 | ALK (0.65) | ALK | |
| SCHEMBL20004111 | 0.82 | ALK (0.61) | ALKSRPK1SRPK2EML4 | |
| SCHEMBL896755 | 0.81 | ALK (0.65) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |