SCHEMBL20004687

SCHEMBL20004687

CCCCOc1ccc(-c2ccc(-c3cc(F)c(C#Cc4ccc5cc(-c6ccc(C)cc6)ccc5c4)c(OC)c3)cc2F)c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 1/20 0.37
RARB P10826 1/20 0.37
ERN1 O75460 1/20 0.37
CD274 Q9NZQ7 1/20 0.35
MCHR1 Q99705 1/20 0.34
AAK1 Q2M2I8 1/20 0.33
MAOB P27338 2/20 0.33
PDE2A O00408 1/20 0.33
PDE10A Q9Y233 1/20 0.33
PDGFRB P09619 1/20 0.33
PDGFRA P16234 1/20 0.33
CYP2C9 P11712 2/20 0.33
MOGAT2 Q3SYC2 2/20 0.33
ACACB O00763 2/20 0.32
ABCB1 P08183 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
MAOA P21397 1/20 0.32
MGAM O43451 4/20 0.32
GAA P10253 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005217 0.97 ERN1 (0.37) RARARARBERN1CD274MCHR1
SCHEMBL20004857 0.94 RARA (0.40) RARARARBERN1MCHR1AAK1
SCHEMBL19999493 0.94 RARA (0.35) RARARARBERN1CD274MCHR1
SCHEMBL20005283 0.93 ERN1 (0.38) RARARARBERN1CD274MCHR1
SCHEMBL20004775 0.92 ERN1 (0.40) RARARARBERN1MCHR1AAK1
SCHEMBL19999624 0.87 RARB (0.38) RARARARBERN1MCHR1ACACB
SCHEMBL19999458 0.85 RARA (0.42) RARARARBERN1MCHR1MAOB
SCHEMBL19999581 0.84 CYP17A1 (0.32) CD274
SCHEMBL20004831 0.84 ERN1 (0.38) RARARARBERN1MCHR1MAOB
SCHEMBL19999407 0.84 RARA (0.40) RARARARBERN1MCHR1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed