Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20005141 | 0.84 | SNCA (0.63) | SNCAMAPTAPPKDM4ESMN1; SMN2 | |
| SCHEMBL20005119 | 0.82 | SNCA (0.50) | SNCAMAPTAPPKDM4ESMN1; SMN2 | |
| SCHEMBL20004443 | 0.75 | SNCA (0.60) | SNCAMAPTAPPKDM4ESMN1; SMN2 | |
| SCHEMBL20005117 | 0.73 | SNCA (0.49) | SNCAMAPTKDM4ESMN1; SMN2KIT | |
| SCHEMBL20004553 | 0.73 | SNCA (1.00) | SNCAMAPTAPP | |
| SCHEMBL20004597 | 0.70 | SNCA (0.94) | SNCAMAPTAPP | |
| SCHEMBL22537869 | 0.68 | SNCA (0.62) | SNCAMAPTAPPSMN1; SMN2 | |
| SCHEMBL20004522 | 0.68 | SNCA (0.72) | SNCAMAPTAPP | |
| SCHEMBL8328576 | 0.64 | AURKA (0.42) | MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL20004397 | 0.63 | SNCA (0.73) | SNCAMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515912-B1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NAT RECH SCIENT (FR) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018055316-A1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-03-29 | — | — | WO | disclosed |