SCHEMBL20005190

SCHEMBL20005190

Cc1ccc(-c2ccc(C#Cc3c(C)cc(-c4ccc(C)cc4)cc3F)c(F)c2)cc1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 13/20 0.40
CYP11B2 P19099 13/20 0.40
AR P10275 1/20 0.39
CYP1A2 P05177 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C19 P33261 1/20 0.33
EGLN2 Q96KS0 1/20 0.31
KIF11 P52732 1/20 0.30
PTGS2 P35354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20006875 0.88 RARB (0.36) CYP11B1CYP11B2ARCYP1A2MAPT
SCHEMBL20005191 0.86 RARB (0.42) CYP11B1CYP11B2MAPT
SCHEMBL20004637 0.84 GRM5 (0.37) CYP11B1CYP11B2CYP1A2MAPTCYP2C19
SCHEMBL20005221 0.84 GRM5 (0.37) CYP11B1CYP11B2CYP1A2MAPTCYP2C19
SCHEMBL20005246 0.81 ESR1 (0.36) CYP11B1CYP11B2CYP1A2MAPTCYP2C19
SCHEMBL12011040 0.80 CYP11B1 (0.43) CYP11B1CYP11B2ARCYP1A2MAPT
SCHEMBL20004620 0.80 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL20004633 0.80 ACHE (0.39) KIF11
SCHEMBL19999459 0.79 RARB (0.43) MAPT
SCHEMBL20004890 0.79 CYP1A2 (0.35) CYP11B1CYP11B2CYP1A2MAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed