SCHEMBL20005222

SCHEMBL20005222

CCc1cc(-c2cc(F)c(F)c(F)c2)c(F)cc1C#Cc1c(F)cc(-c2ccc(C)cc2F)cc1F

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
KDM1A O60341 1/20 0.31
CTSA P10619 1/20 0.30
PDE9A O76083 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005292 0.82 AKR1C3 (0.32) AKR1C3AKR1C2KDM1A
SCHEMBL19999482 0.82 RARB (0.42)
SCHEMBL19412665 0.77 FFAR1 (0.32) AKR1C3AKR1C2KDM1ACTSA
SCHEMBL18622099 0.76 PDE3B (0.33) AKR1C3AKR1C2
SCHEMBL12889472 0.75 PTGS2 (0.40) AKR1C3AKR1C2KDM1ACTSA
SCHEMBL20005256 0.73
SCHEMBL20005255 0.73
SCHEMBL20005231 0.72 FFAR1 (0.34) KDM1A
SCHEMBL19412666 0.72 PDE3B (0.33) AKR1C3AKR1C2KDM1A
SCHEMBL19999570 0.72 RARB (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10208249-B2 Liquid crystal compound, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2019-02-19 US disclosed
US-20180086979-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2018-03-29 US disclosed
EP-3299439-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2018-03-28 EP disclosed